SmithKline's Avandia Prescriptions Top 11,000 a Week, NDC Says 
       Bloomberg News      July 14, 1999, 7:32 p.m. ET 
       SmithKline's Avandia Prescriptions Top 11,000 a Week, NDC Says
       London, July 14 (Bloomberg) -- SmithKline Beecham Plc's      diabetes pill Avandia captured more than 11,200 new prescriptions      in the week ended Sunday, according to NDC Health Information      Services.
       That gave Avandia, which won U.S. approval in May, about      2.6 percent of the market for new diabetes prescriptions, said      NDC's DirectRx Service, which tracks prescription sales at U.S.      pharmacies. The drug has had more than 45,000 new prescriptions      and refills since its June introduction, NDC said.
       Avandia is part of a new class of diabetes pills that help      some people manage their disease without insulin shots. Avandia      is seen as a successor to a similar medicine, Rezulin. Rezulin is      a Sankyo Co. drug that Warner-Lambert Co. markets.
       About 1.6 million people have tried Rezulin since the drug's      1997 introduction. In some cases, the drug worked where other      medicines had failed. That spurred demand for Rezulin. The drug's      sales rose 78 percent to $748 million in 1998.
       Analysts have said 1998 sales likely will be the peak for      Rezulin, which has been linked to fatalities and cases of serious      liver damage. The FDA has several times added restrictions to the      drug's warning label.
       Avandia and another Rezulin rival, Takeda Chemical      Industries Ltd.'s Actos, so far seem less likely to cause liver      damage than Rezulin is.
       New prescriptions for Rezulin fell to about 29,450 in the      week ended Sunday from about 33,230 in the week ended May 2,      according to NDC. The drug's share of the new prescription market      fell to 6.8 percent from 7.8 percent.
       Analysts expect the U.S. Food and Drug Administration to      approve Actos within the next week. Eli Lilly & Co., one of the      world's top-sellers of insulin, will help Takeda market Actos in      the U.S.    |