Thank you. I just started to find them with a search for authors.
5% Carbon Dioxide in Inspired Air Increased a Deposition of Liposome Aerosol of Anticancer Drugs, 9-Nitrocamptothecin and Paclitaxel, in Mice.
Nadezhda V. Koshkina, Vernon Knight, Luz Roberts, Eva Golunski, Clifford J. Waldrep, Baylor College of Medicine, Houston, TX.
Increased concentrations (3-7%) of carbon dioxide in inhaled air increase pulmonary ventilation. We examined whether this procedure would improve pulmonary deposition of inhaled liposome aerosols containing 9-nitrocamptothecin (9NC) and paclitaxel (PTX) drugs. ICR mice were exposed for 30 minutes to each liposome
aerosol drug generated with and without 5% CO2-air mixture (v/v). Tissue distribution of two drugs sampled over two-hour time period was determined in both groups of mice. Significantly higher concentrations of 9NC and PTX were found in the lungs of mice treated with 5% CO2-air and ranged from 2-4-fold higher than in the animals
treated with normal air. Similar increased concentrations were found in liver, kidneys, spleen, blood and brain of mice breathing the CO2-enriched air. The increased concentration of CO2 in the air did not change tissue distribution patterns of the drugs. These findings support the continued evaluation of more effective methods for
lung cancer treatment by using aerosol delivery systems. |
