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Biotech / Medical : Regeneron Pharmaceuticals
REGN 751.11-2.6%Jan 28 3:59 PM EST

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To: scaram(o)uche who wrote (91)5/3/1997 3:34:00 PM
From: Miljenko Zuanic   of 3559
 
Rick,

Glad that you correct me regards TKTX. I didn't checked last night and this morning I sow that I misunderstand part of the questions.

CNTF is on *trial*, no BDNF.

Acquisition of the Syntex amgn got in possession patent covering *moc* for CNTF. Regn has patent covering receptor for CNTF. Also, before Syntex acquisition, regn and Syntex was in patent dispute regarding the *moc* patent. I thing, for now, this litigation is on hold, and regn has back-fire opportunity if amgn move to far from their partnership.

Ctii will have (IMO) to license right from amgn and regn. This will be very difficult under current condition. Developing implant-CNTF for ALS they tested their technology in field. With current development in research for neuroprotective/grow factors it seams that combination of two or three will have better chance. This is regn Oxokime (combination of the CNTF and NGF) and ctii/gne NT-4/5 + CT-1 (chimeric CNTF).

The future is on delivery method for large peptide and/or small chimirc molecule (regn-pcop).

Regards the ARQL, their secondary offering is to rise cash which they need for expansion-acquisition of the smaller collaborators. Large library of the organic molecules needs biological targets and assays.

mz
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