SARS and Avian Flu Message Board

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Biotech / Medical : SARS and Avian Flu

Public Reply Prvt Reply Mark as Last Read File

Previous 10 Next 10 Previous Next

To: Biomaven who wrote (962)	8/27/2003 9:02:05 PM
From: Henry Niman	of 4232

Peter the two genes, M and N are fairly close to each other. For M 235 bp were sequenced and for N it was 589. Thus, the actual sequence is 844 nucleotides. In twelve samples the sequence was an exact match (844/844) for Tor 2 (and many other SARS CoVs isolated after the virus broke out internationally) and the other sample was identical (844/844) to Frankfurt 1 (and 3 other known sequences, all linked to the Metropole Hotel). The region sequenced is about 3000 nt from 5' to 3' so the two regions cover about 10% of the SARS CoV genome. The fact that two viruses were identified strongly suggests that they are not recombinants or mutants because the Winnipeg labs have identified TWO SARS CoVs. The simplest explanation is probably correct. There are at least two SARS CoVs in Surrey. BC and they look just like the viruses that started the outbreak in Toronto (Tor2) or the virus from the physician who was quarantined in Frankfurt when he was returning from an infectious disease meeting in NYC. Some patients also are infected with OC43, a cold virus sharing limited homology with Tor2 or Frankfurt 1 but certainly not enough to explain the sequence data and probably not enough to explain the antibody data.

Report TOU Violation

Share This Post

Public Reply Prvt Reply Mark as Last Read File

Previous 10 Next 10 Previous Next