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Biotech / Medical : Biotech Valuation

CRSP 56.87

-2.3%

Dec 5 9:30 AM EST

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To: Biotech Jim who wrote (9943)	1/7/2004 5:20:34 AM
From: Henry Niman	of 52153

BJ, The direction of the transfer is difficult to determine, but some of the civets are quite "humanized". I haven't seen the latest data but SZ3 has 4 polymorphisms seen in all human isolates, two seen in an early health care worker (in Guangzhou), and one in a fatal Amoy Gardens case (these 7 polymorphisms are not in the other 3 animal sequences at GenBank) The linkage is quite strong and if it is because humans are infecting civets, then those animal sequences at GenBank link back to earlier cases (none have the 29 nt deletion, but virtually all human SARS from last season do (GZ01/GD01 is the only human isolate with the 29 nt). However, the animal isolates now are being reported as being more "humanized", which certainly sounds like humans infecting civets. Its probably a two way street (experimentally many species including domestic cats and ferrets) can be infected by fully mutated human isolates, including those with the 29 nt deletion), which is why the civets are being culled.

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