eDrugstores: Drugstore.com, PlanetRx and Soma Message Board

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Technology Stocks : eDrugstores: Drugstore.com, PlanetRx and Soma

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To: Tom D who wrote (90)	6/16/1999 2:43:00 PM
From: Firenze	Read Replies (1) of 254

Tom D Your information related to the drug Rezulin is inaccurate. Rezulin does not increase insulin levels, it reduces them. Twenty-five (25) deaths have been associated with Rezulin. Avandia, is an excellent drug, but there have been no reported cases of liver failure in Rezulin patients after the initial 8 months of therapy. There really is no complelling reason to actively switch a patient to Avandia, unless the patient requests it. You should also note that all patients with diabetes will gain 5-7 pounds in the initial phases of treatment, if they are achieving glycemic control. The UKPDS study showed that weight gain did happen with Glucophage. Amaryl is a sulfonylurea increases insulin levels. Rezulin and Avandia are the only approved drugs in their class and would never be interchanged with Amaryl and should not be. That being said you are completely correct regarding PlanetRX, they will not have a chance at entering the networks of big MCOs and PBM, as a matter of fact, those companies look at PlanetRX as a competitor. Let me know your thoughts. Firenze

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