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Biotech / Medical : Regeneron Pharmaceuticals

REGN 647.19

+0.5%

Nov 6 3:59 PM EST

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To: Dr. John M. de Castro who wrote (309)	6/18/1999 11:19:00 PM
From: Miljenko Zuanic	Read Replies (1) of 3557

Thanks John. Seams interesting scientific stuff, still majority of it was already known (I didn't read full article so I may be bit out of line here) about Angio-x functions in neovascularization and tumor growth. Investor do not buy, not anymore, this kind of story. What we need is clear statement from REGN: what is their business plan in regards the Angio-x proteins and how they will implement this plan??? In PRnews they wrote hints like: <<In particular, our findings support drug development based on blocking VEGF action, which Regeneron and others are aggressively pursuing.>> How they are blocking VEGF action??? What agent? or <<This may provide the opportunity to use Angiopoietin-2 as a diagnostic tool to allow imaging of small tumors and metastases, and perhaps even as a handle to allow targeting of chemotherapeutic agents specifically to tumor tissue.>> Angio-2 + WHAT for imaging??? ... and is TIE-2 selective (as natural Angio-2 receptor) expressed on tumor cells to allowed designee targeted Angio-2+chemo agents??? Miljenko

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