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Biotech / Medical : ARIAD Pharmaceuticals
ARIA 23.990.0%Feb 17 4:00 PM EST
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To: BridgeTech who wrote (572)6/19/1999 2:29:00 PM
From: Mike McFarland  Read Replies (2) of 4474
 
BridgeTech: You remind us in your initial
release that ARIA has rights to 50% of
the validated targets and proteins that
emerge from the JV (with Hoechst).

and you wrote:
Coming Milestones — BUYing Opportunity
Clinical: During 1999, we expect ARIA to commence
a Phase II trial for its GvHD product and to hear
of advancements in its osteoporosis and other
product programs.

and we know from the February osteo PR that
HMR has exclusive rights to commercialize
these drugs worldwide for the treatment of osteoporosis
and related bone disease. ARIAD has the right, under
certain circumstances, to participate in the development
and commercialization of these products for nonosteoporosis
indications in North America.

SH3 domain Src...here are a couple urls
sdsc.edu
the SH2 domain binds a specific phospho-tyrosine of the
receptor and SH3 domain binds and recruits Sos, a GTP Exchange
Factor (GEF), to the membrane. Sos is activated by this membrane
localization. Sos activates Ras

embl-heidelberg.de

I'll scan my annual report and see if there were any hints
in there later...but for now, any comments BridgeTech?
I also have the "ras by sos" article that is in the free
online issue of Nature Biotech...the puzzle game is an
entertaining distraction for me when I surf the net...but
again, how about some comments on the subject--
BridgeTech?
SI_Bio_Gurus?
Ariad?
Anybody?

nonosteoporosis indications
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