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Strategies & Market Trends : Biotechnology Cancer Cures
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To: scaram(o)uche who wrote (73)6/22/1999 1:38:00 AM
From: SnowShredder  Read Replies (1) of 226
 
Hi Rick, Thanks for the quick response...I'll have to look for it. I remember reading the Science article from Nov 98, but it didn't mention any company, that I can remember. I heard that there was a presentation on the Reovirus therapy @ the recent ASGT meeting in D.C. From the summary that I got, it sounded very promising.

A couple of other interesting tid bits from the summary that I got was that in females 40-50 yrs old ~39% have abnormal cells in their breasts...in males ~40 yrs old 100% have abnormal cells in their prostate...in that they are in a dormant state. We're the lucky ones, huh ;) The study was done by taking tissue crosssections of the breast & prostate from people who died of car accidents.

Also Folkman said that angiostatin causes growing cancer cells to go into a dormant state... dormant cancer cells can exist via diffusion if they are <0.25mm-.04mm in size, and that vasculature is required if they are >1.0mm in size.

A little tumor biology...a primary tumor secretes both VEGF & angiostatin. VEGF is cleared in ~3 min...and allows the primary tumor to grow vasculature. Angiostatin is cleared in ~2 1/2 days, thus inhibiting the growth of secondary tumors. If this is the case, then metastises grow after the primary tumor is removed because the angiostatin is no longer secreted...the secondary tumors switch from the dormant state into the active state, and thus all growing @ once.

Best of Luck, Where'd He Go?
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