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Non-Tech : Bill Wexler's Dog Pound

REFR 1.600

-8.5%

Nov 6 3:59 PM EST

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To: sun who wrote (1859)	7/11/1999 12:36:00 AM
From: BDR	Read Replies (1) of 10293

ama-assn.org Abstracts - May 19, 1999 Efficacy of Tremacamra, a Soluble Intercellular Adhesion Molecule 1, for Experimental Rhinovirus Infection Results A total of 88 (92%) of the 96 subjects in the placebo groups and 69 (85%) of the 81 subjects in the active treatment groups were infected (P=.19). For placebo vs tremacamra, respectively, the total symptom score (± 95% confidence interval [CI]) was 17.6 (± 2.7) vs 9.6 (± 2.9), the proportion of clinical colds was 64/96 (67% ± 9%) vs 36/81 (44% ± 11%), and the nasal mucus weight was 32.9 (± 8.8) g vs 14.5 (± 9.4) g (P<.001 for all comparisons). Tremacamra was not associated with adverse effects or evidence of absorption through the nasal mucosa and did not interfere with development of neutralizing antibody. Conclusion Tremacamra reduced the severity of experimental rhinovirus colds. Whether tremacamra will be useful clinically will require further study. Because of the small numbers of subjects the initial difference in rate of infection could have been a random event and not due to the intervention (p=.19) and so I am not sure how significant any of the other differences noted were.

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