Hi Mike,
I just read my July issue of Nature Biotech and found an article that has some interesting ideas on BT in general and some specifics on cancer (Metabolic control analysis in biotechnology and medicine, p 641). One of the cancer specifics is the enzyme transketolase, which "might play a major role in the control of the nonoxidative pentose-phosphate pathway in cancer cells." I used Medline to find references to publication by the speaker (the article is a summary of a workshop) and found the abstract below. I couldn't find any companies working with transketolase, but it looks like something worth watching for.
Jason
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Title
Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism?
Author
Boros LG; Lee PW; Brandes JL; Cascante M; Muscarella P; Schirmer WJ; Melvin WS; Ellison EC
Address
Department of Surgery, The Ohio State University College of Medicine, Columbus 43210, USA. lboros@magnus.acs.ohio-state.edu
Source
Med Hypotheses, 1998 Jan, 50:1, 55-9
Abstract
Pentose phosphate pathways (PPP) are considered important in tumor proliferation processes because of their role in supplying tumor cells with reduced NADP and carbons for intracellular anabolic processes. Direct involvement of PPP in tumor DNA/RNA synthesis is not considered as significant as in lipid and protein syntheses. Currently, PPP activity in tumor cells is measured by lactate production, which shows a moderate activity: about 4% to 7% compared with glycolysis. Recent data generated in our laboratory indicate that PPP are directly involved in ribose synthesis in pancreatic adenocarcinoma cells, through oxidative steps (< 31%) and transketolase reactions (69%). These findings raise serious questions about the adequacy of lactate in measuring PPP activity in tumors. We hypothesize that ribose, not lactate, is the major product of PPP in tumor cells. Control of both oxidative and nonoxidative PPP may be critical in the treatment of cancer. PPP are substantially involved in the proliferation of human tumors, which raises the prospect of new treatment strategies targeting specific biochemical reactions of PPP by hormones related to glucose metabolism, controlling thiamine intake, the cofactor of the nonoxidative transketolase PPP reaction, or treating cancer patients with antithiamine analogues.
Language of Publication
English
Unique Identifier
98147507 |
