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Biotech / Medical : IMMUNE NETWORK RESEARCH (VSE:IMM)

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To: pete meyer who wrote (33)	4/2/1997 9:29:00 PM
From: burner	of 134

Immune Network Research Ltd - News Release CTB-1 research continues Immune Network Research Ltd IMMShares issued 199704521997-02-10 close $0.16Wednesday Apr 2 1997News ReleaseMr Michael Grant reports Further research related to the safety feasibility study of CTB-1 in non-human primates macaque mulata revealed that CTB-1 injection increased virus-neutralizing antibody levels in monkeys chronically infected with SHIV IIIB. SHIV IIIB is a recombinant retrovirus designed to allow study of anti-HIV immune responses in macaque monkeys. This work was carried out by Dr Sybille Muller and Dr Heinz Kohler of the University of Kentucky in collaboration with scientists at the New England Regional Primate Center and the US National Cancer Institute. The US patent office has given notice of allowance of certain patent claims on the monoclonal antibody CTB-1 and its use in respect of HIV infection. Laboratory analysis of plasma samples taken from the macaques receiving CTB-1 demonstrated a rapid rise in the potency of antibody neutralization of SHIV IIIB and HIV MN following CTB-1 injection. This indicates that CTB-1 stimulated de novo production of broadly neutralizing anti-HIV antibodies in the infected macaques. Studies are now under way to test whether monkeys that have developed symptoms of retrovirus-induced immunodeficiency benefit from CTB-1 injection in terms of lower virus load, lymphocyte subset normalization or longer disease free survival. If results from these next studies are favourable, the company would proceed to seek approval for clinical trials to determine if CTB-1 has beneficial effect on the immune system and on disease progression in human HIV infection. The company has engaged the services of Dr Muller and Kohler Trough Immpheron, Inc to produce more CTB-1 monoclonal antibody, continue the macaque studies and coordinate the research with collaborating scientists. The board of directors is continuing its due diligence with respect to the proposed business combination with Bio-Fluorescent Technologies, a public US company, in preparation for consideration of this matter at the upcoming annual general meeting. Trading of the company's shares remains halted at the request of the VSE pending necessary shareholder and regulatory approvals of the transaction. (c) Copyright 1997 Canjex Publishing Ltd. canada-stockwatch.com old url (better for printing)

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