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Biotech / Medical : Celgene-CELG

CELG 108.24

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Nov 22 4:00 PM EST

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To: A.J. Mullen who wrote (357)	9/10/1999 11:22:00 AM
From: Biomaven	Read Replies (1) of 804

AJM, The duration of 5mg of the single isomer is indeed longer than that of 10mg of the original - see the preceding posts for details. I'm not sure if the reason for this is fully understood. For an example of how this can happen, one model is SEPR's single isomer albuterol, Xopenex. There the "evil twin" not only has a longer half-life than the good guy, but also interferes with its effectiveness. There it turns out that you can give the single isomer in a quarter of the dose of the racemic mixture and get equivalent efficacy and a longer duration of action. My guess is that something similar is happening with Ritalin, although I don't think here there is any suggestion that the discarded isomer is actually harmful, just that it plugs up the works in some way, maybe by binding to the relevant receptor(s) or otherwise competing with the good isomer. The plasma concentration of the good isomer is approximately the same as when you give double the dose of the racemic, so it's probably not an absorption issue. Peter

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