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Biotech / Medical : Gene therapy

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To: Gordon James who wrote (154)	9/12/1999 4:55:00 PM
From: Mike McFarland	Read Replies (2) of 319

Thread: Recently, on another thread, I asked if cancer is the best target for gene therapy right now--what do you folks have to say? Lately there has been more discussion of vectors, but are the problems associated with perfecting a vector--making it less immunogenic--really much of a problem if transfecting CTLs in a petri dish, maybe not? I think you know where I am going with this... If an infusion of CTLs cured a cancer, who cares if you cant use that particular vector again later. I understand this loops back around to the GvH/GvL--just trying to stimulate some discussion. Would it be useful to sort the in vivo trials from the in vitro trials? How do you fellas classify a gene therapy trial when you hear about one? I've read that restoring function of a missing gene-- restoring levels of a single protein is where the first successes will be in Gene Therapy--hemophilia, CF etc. And yet I count up the trials and most are for cancer. Finally, what do MAbs have to do with Gene Therapy? __ what are CD34+ cells? --Are those Cytotoxic T cells too?

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