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To: Jenna who wrote (62737)9/23/1999 12:13:00 PM
From: lizard lick  Read Replies (2) of 120523
 
GERN related news out just now on stem cell
A: Stem Cells May Help Muscle Disease
(Comtex 09/23 11:58:44)

BOSTON, Sep 23, 1999 (AP Online via COMTEX) -- Researchers have found
that bone marrow transplants might be a new way to restore strength to
patients with muscular dystrophy and other muscle-wasting diseases.

In very preliminary experiments, scientists at Children's Hospital
infused mice weakened with muscular dystrophy with bone marrow stem
cells taken from healthy donor mice.

The stem cells generated new bone marrow and blood cells in the sick
mice, whose own bone marrow had been destroyed with radiation. The stem
cells also generated healthy, mature muscle cells that traveled through
the blood stream to ravaged skeletal muscles and to a certain extent,
restored them.

If the immature bone marrow stem cells can generate muscle cells, they
also might prove to be a source of repair cells for other kinds of
tissues in the body, said scientists led by Richard Mulligan and Louis
Kunkel of Children's and Harvard Medical School.

The findings are important because 'in adult tissues we may have a
reservoir of stem cells that has more potential than we think' to
differentiate into other types of cells, said Emanuela Gussoni, a
biologist in Kunkel's lab and lead author of the paper in today's issue
of the journal Nature.

In a related experiment, Gussoni and her colleagues isolated muscle
stem cells from mice and demonstrated they could generate adult muscle
cells as well as bone marrow cells.

Dr. Leon Charash, chairman of the medical advisory committee of the
Muscular Dystrophy Association, told The Boston Globe that the findings
were 'exciting' because 'the work may eventually lead to an
unanticipated treatment approach for all the muscles ravaged by
neuromuscular disease.'

Copyright 1999 Associated Press, All rights reserved.

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APO Priority=r
APO Category=1500

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