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Biotech / Medical : GLGC Gene Logic

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To: Steve Push who wrote (81)	9/25/1999 8:59:00 AM
From: Greg Jung	Read Replies (1) of 360

Thanks for the info. I fixed my computer problem and was able to read the info on the web site. Let me see if I've got this correct: quote "Unlike other probe arrays, the Flow-thru Chip has hundreds of thousands of discrete microscopic channels that pass completely through it. Probe molecules are attached to the inner surfaces of these channels, and molecules from the samples to be tested flow through the channels, coming into close proximity with the probes. This closeness facilitates the intended reaction between the probe and the test molecule. " So, the many channels are loaded with a single drug lead, a reaction is invoked by passing the targetted substance through, and the reacted mixture in the several thousand containers is analysed by the chip, one aspect of the gene expression per channel? Or are different lead compounds loaded into the channels which are uniformly analysed for a single effect? In any event, are these chips one-use only and if not, how does one remove the residue of a previous test to proceed with the next? Thanks in advance, Greg T

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