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Biotech / Medical : Cel-Sci Corp (AMEX:CVM) (was HIV)
CVM 5.160+3.4%Jan 16 3:59 PM EST
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To: Jerry A. Balcolm who wrote (2722)11/3/1999 6:27:00 PM
From: Tom Shutters  Read Replies (3) of 2836
 
"Virus-cell interaction provides new HIV vaccine target"

..."Much research is currently focused on the mechanism of HIV entry into cells and could lead to the development not only of antiretroviral drugs but also vaccines, Dr. Anthony S. Fauci commented at the 12th Colloque des Cent Gardes held here this week"...

..."And that part, which is just very briefly exposed during the conformational change of the gp120 and gp41, is now the subject of targets for small peptides to bind it." Most of the presentations concerning viral entry address this concept either directly or indirectly."

"This is an area of "considerable hot interest" now, Dr. Fauci pointed out. Research efforts are concentrated around designing peptides that interfere with the binding of the epitopes that are hidden until the point of fusion."

"There's no doubt that the peptides will work in inhibiting binding," he continued. The critical question is "...can you get it in the form that can be administered so the concentration of the peptide would be appropriate and pharmacologically relevant enough to do the blocking."

"The problem with peptides is that they are large molecules that have difficulty getting into the mucosa of the gut. Right now, these molecules are administered by injection. Once researchers get them into a "...soluble form that is orally available...I think you're going to have something that is really hot."...

..."We may be able to "...exploit what looks like an Achilles' heel of the molecule," Dr. Ruprecht said. It also looks like "...the problem of clades may not be as difficult to overcome as we previously thought."

ama-assn.org
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