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Biotech / Medical : Vertex Pharmaceuticals (VRTX)

VRTX 435.84

+0.4%

2:11 PM EST

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To: Miljenko Zuanic who wrote (360)	11/21/1999 5:29:00 PM
From: Casaubon	Read Replies (2) of 1169

it should be possible to design, based on the structure of FK506, non-FKBP-12-binding (nonimmunosuppressant) compounds That's the easy part. We did that for years! Does Timcodar promote neurite outgrowth? Or, does small molecule ligand which bind to FKBP-12 actually also bind to PKBP-52 (new ligand for FK506) and enhance wonted effects? Are you asking if Timcodar promotes neurite outgrowth directly, or requires a FKBP mediated binding event? I doubt Timcodar functions directly on neurite outgrowth as the presence of NGF is necessary to promote nerve growth. Whether or not it is an FKBP mediated event is debateable.

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