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Biotech / Medical : ARIAD Pharmaceuticals

ARIA 23.99

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Feb 17 4:00 PM EST

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To: LLCF who wrote (757)	11/29/1999 3:42:00 PM
From: Mike McFarland	Read Replies (1) of 4474

Anybody read "Mutant mice live longer" Nature Vol 402, 18 Nov--p243, and also see p309 for the paper We propose that p66^shc is part of a signal transduction pathway that regulates stress apoptotic responses and life span in mammals. Caught me eye because three of the proteins mentioned share a SH2 domain, and in the news and views article an analogy is made to p53 (tumor supressor). I generally only read the weather and climate papers...the biotech letters fly pretty far over my head, but do check out page 243 if you subscribe. When I see SH2 naturally I think of Ariad, but mainly I wanted to note an interesting article and this seemed as good a place as any to park misc. signal transduction stuff.

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