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Biotech / Medical : AVIGEN(avgn)

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To: jay silberman who wrote (176)	12/2/1999 2:15:00 AM
From: Mike McFarland	Read Replies (1) of 228

You may be thinking of this: Seattle researchers uncover structure of blood- clotting protein involved in most common form of hemophilia eurekalert.org I don't want to cut and paste too much from the release, but this quote I think is rather important: In theory, we could make a whole battery of variants of recombinant human factor VIII that could be administered one after another," Stoddard says. "When a patient develops an immune response to one, they could switch to another version of the protein. I seem to remember Avigen was doing something like desensitizing, much like what an allergist would do to deal with immune response. Gosh, wouldn't it be great if a person could receive the missing gene, but then just take a pill if they cut themself-- too simple? Change the dosage to deal with the immune response and declining level of expression. Oh, am I going to get flamed for that one! A whole can of spam in one serving. (I got good news from the folks at Swedish perinatal today...guess I am still all wound up from relief, folks who know me can see the GMO thread for details. And I promise to stay off Avigen thread from now on and go back to my hole on the Ariad thread, heheh)

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