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Biotech / Medical : CLTR COULTER PHARMACEUTICAL

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To: biowa who wrote (414)12/2/1999 10:26:00 AM
From: Bob L  Read Replies (1) of 666
 
<<Zevalin is given in a dosage independent of dosimetry in the PIII isn't it? >> It doesn't exactly look like it from the phase III protocol I downloaded from NIC PDQ some time ago:

"Patients receive rituximab IV immediately followed by an imaging dose of
IDEC-In2B8 IV over 10 minutes on day 1. Patients meeting the dosimetry
requirements receive rituximab IV over several hours and IDEC-Y2B8 IV over 10
minutes on day 8."

But I don't know what they mean by "meeting the dosimetry requirements." Maybe that just means they can measure the distribution and estimate the radiation dose to various organs as a monitoring thing rather than using dosimetry to estimate the dose. Maybe they need a different word than "dosimetry."
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