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Pastimes : The Justa & Lars Honors Bob Brinker Investment Club

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To: Mike McFarland who wrote (10262)	12/5/1999 1:03:00 PM
From: marc ultra	Read Replies (1) of 15132

OT Mike, just noticed that link you posted on ENMD and wanted to make one last comment. BMY did fail miserably in their attempt to make angiostatin. Without rehashing the story I can tell you that ENMD and its contract supplier Covance are using a yeast expression vector Pichia Pastoris and making all the recombinant human Endostatin they need for trials and scale up to large volumes are unlikely to be a problem. Also apparently angiostatin is even easier to make in this system than endostatin. BMY not only failed here but they also passed when offered to partner on thalidomide by ENMD. If you wish to follow what is going on with these the ENMD discussion has primarily moved to Raging Bull due to problems with Yahoo while the ISIP discussion is mostly on Yahoo. SI is dead due to lack of any critical mass of posters on these small biotechs. Anyway I've probably imposed enough off topic stuff here for now. Marc

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