GUMM - Eliminate the Common Cold Message Board

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Biotech / Medical : GUMM - Eliminate the Common Cold

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To: Ohshaw who wrote (1808)	12/6/1999 12:24:00 AM
From: DanZ	Read Replies (1) of 5582

Ohshaw, Dr. Epstein can probably do a better job of answering your question, but he's out of the country right now and might not be reading this board often. I'll do my best to answer your question for now and Dr. Epstein can follow up later and tell me where I messed up <g>. The portal of infection for the rhinovirus is the ICAM-1 receptors on the nasal epithelium. It is my understanding that these receptors are not all over the nasal cavity as you have expressed. They are located near the opening of the nose, and that's why the directions that come with Zicam instruct the patient to insert the tip just past the opening and aim the applicator up towards the roof of the nose. When you squeeze your nose, the gel adheres to the area where the ICAM-1 receptors are located. If Zicam was a spray, rather than a gel, it wouldn't work. The gel matrix is key to ensuring that the zinc ions aren't repelled and that they remain in contact with the ICAM-1 receptors long enough to interrupt the replication of rhinoviruses. Best regards, Dan

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