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Biotech / Medical : BIOMIRA RESEARCH (BIOM)
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To: chirodoc who wrote (19)12/12/1999 9:33:00 PM
From: chirodoc  Read Replies (1) of 72
 
ON BLP-25, BIOMS "OTHER" VACCINE AND PATENTS

thanks rp

No need for me around here anymore, bit-man has the science down cold on this comparison between Transgene and BIOM. The Biom license of the two key patents (Kufe, Harvard and Taylor ICRF) is for an exclusive using synthetic or recombinant produced. Not covered are viral expression systems used of MUC1 avccine delivery. Covered is peptides/proteins in any formulation of a vaccine. It is important to note that the results are encouraging and the approach also uses IL-2. My understanding of the data to date has been that levels of expression were still quite low, thus to see positive results means things could be very interesting in January when BLP25 cactually gets combined with Lipo-IL2 for the first time. The results with BLP25 (high dose) by its self should soon be known, and will be positive I am sure. The combo, in which the synthetic appraoch allows for accurate and consistent doses of both peptide/adjuvant and IL-2 in a slow release format. Published mouse models and the limited human data available show this combination is consistently able to effect tumors in a wide variety of systems. This combo is as exciting a product candidate as this company has had.
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