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Biotech / Medical : Ligand (LGND) Breakout!
LGND 203.18-1.4%Nov 28 9:30 AM EST

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To: William B. Kohn who wrote (29587)12/13/1999 3:02:00 PM
From: Cheryl Galt  Read Replies (2) of 32384
 
Plenty of sugar!

Once approved and on the market, a drug seems to enter many additional studies at various university cancer centers, exploring new indications and combinations -- at no expense to the company except for perhaps supplying the drug.

I'm especially looking forward to seeing Targretin tested in combinations.

Also, individual doctors will soon be free to try Targretin on various cancer patients who have become resistant to other drugs, or for whom other chemo is too toxic.
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RE the turn-down for early-stage (7/5 with 4 abstentions):

My *guess* is that the objectors and abstainers wanted a larger sample size.

In the open-label early-stage study, there were only 28 patients
in the 300 mg/m2/day initial dosage level that was submitted for NDA approval.

(2/28 patients had complete remission.
13 others had a partial response of at least 50% remission.)

Any other ideas anyone??
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