Cambridge NeuroScience and Algos Pharmaceutical Establish Licensing Agreement For Pain Products ***************************************************************** I have NO Position in CNSI, just watch it ************************************************************ CAMBRIDGE, Mass., and NEPTUNE, N.J., Jan. 4 /PRNewswire/ -- Cambridge NeuroScience, Inc. (OTC Bulletin Board: CNSI) and Algos Pharmaceutical Corporation (Nasdaq: ALGO) today announced the companies have entered into an agreement to enhance each company's programs in the field of pain management. Under the agreement, Cambridge NeuroScience has been granted a paid-up license under three Algos patents to develop products discovered by or on behalf of Cambridge NeuroScience for the treatment of pain, and, in exchange, Algos has gained the right to negotiate to develop and/or commercialize these products. "This agreement is attractive for several reasons," stated Harry Wilcox, President and CEO of Cambridge NeuroScience. "As we advance our CNSI 5161 program towards Phase II trials over the next 12 to 18 months, we are strengthening our position in the NMDA-receptor antagonist approach to pain. Moreover, we are excited by the potential synergy in the future between the drug discovery capabilities of Cambridge NeuroScience and the development skills of Algos, especially as they merge with Endo Pharmaceuticals, another major player in the pain field." "This agreement further strengthens our position in the pain management field and complements our recently announced merger with Endo Pharmaceuticals," stated John Lyle, President and CEO of Algos. "Cambridge NeuroScience will strengthen our drug discovery efforts for pain products and, with Endo's top-notch manufacture and commercialization capabilities, we will be well-positioned to bring our products to market." Algos Pharmaceutical Corporation, based in Neptune, New Jersey, is a leader in developing proprietary pain management products. The Company's products combine existing analgesics and anesthetics with NMDA-receptor antagonist drugs. Algos' products currently in development include opioid analgesics for moderate-to-severe pain, non-opioid analgesics for mild-to- moderate pain, long-lasting local anesthetics for post-operative pain, an intranasal anesthetic for migraine and products for the treatment of opiate and nicotine addiction. On November 29, 1999, Algos announced it had entered into a merger agreement, pursuant to which it will merge into a subsidiary of Endo Pharmaceuticals Holdings, Inc. Cambridge NeuroScience, Inc. is a neuroscience company engaged in the discovery and development of proprietary pharmaceuticals focusing on nerve cell survival and function. The Company is developing products to treat pain, as well as stroke and chronic neurodegenerative disorders, such as multiple sclerosis, peripheral neuropathies and other degenerative diseases. This news release contains "forward-looking" statements, within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, that are based on management's beliefs and assumptions, current expectations, estimates and projections. Statements that are not historical facts, including statements which are preceded by, followed by, or that include the words "believes;" "anticipates;" "plans;" "expects;" "estimates;" or similar expressions and statements about Algos or Cambridge NeuroScience are forward-looking statements. Many of the factors that will determine the future results of Algos and Cambridge NeuroScience are beyond the ability of Algos or Cambridge NeuroScience to control or predict. These statements are subject to risks and uncertainties and, therefore, actual results may differ materially. The reader should not rely on any forward-looking statement. Neither Algos nor Cambridge NeuroScience undertakes any obligation to update any forward-looking statements whether as a result of new information, future events or otherwise. Important factors that may affect the future results of Algos and Cambridge NeuroScience include, but are not limited to, uncertainty associated with pre-clinical studies and clinical trials and regulatory approval, uncertainty of market acceptance of new products, reimbursement policies of government and private health insurers, impact of competitive products and pricing, product development, changes in laws and regulations, customer demand, possible future litigation, and availability of future financing. Readers should evaluate any statements in light of these important factors. See "Risk Factors" in Algos' Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. See "Risk Factors" in Cambridge NeuroScience's Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. SOURCE Cambridge NeuroScience, Inc. -0- 01/04/2000 /Contact: Harry W. Wilcox, III, President and Chief Executive Officer of Cambridge NeuroScience, Inc., 617-225-0600, x114 or John W. Lyle, President and Chief Executive Officer of Algos Pharmaceutical Corporation, 732-938-5959 or Carol A. Ammon, President and Chief Executive Officer of Endo Pharmaceuticals Holdings Inc., 610-558-9800 or Media: Theresa McNeely, Director of Feinstein Kean Healthcare, 617-577-8110 or Linda Seaton or Kathy Witz of Mentus, Inc., 858-455-5500, x133/x140/ (CNSI ALGO) CO: Cambridge NeuroScience, Inc.; Algos Pharmaceutical Corporation ST: Massachusetts, New Jersey IN: BIO MTC SU: LIC |