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Biotech / Medical : AVXT RESEARCH THREAD
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To: chirodoc who wrote (22)1/26/2000 2:11:00 AM
From: JerryR   of 35
 
The 98 annual report discusses the AC vaccine technology. "The ...hapten, is recognized by the immune system and elicits an immune response against the larger molecule. The approach is based on the premise that a patient's immune response to a strongly immunogenic, hapten-modified tumor antigen *may* be followed by the development of an immune response to the unmodified tumor antigen, somewhat analogous to the phenomenon of drug induced autoimmune disease. Therefore, the process of haptenizing a patient's tumor cells *may* allow the unhaptenized cancer cells to be recognized by the body's immune system leading to an immune response against the patient's tumor cells and their potential elimination from the body." (I've emphasized the mays.)
The results for the survival of stage 3 patients at 5 years being 55% vs 20% in the controls and vs 32% for the high dose alpha interferon seem wonderful and I do not try to minimize their importance or validity. What bothers me is that haptenization changes the antigen. So how does that facilitate a response against the tumor antigen? Is there a theory as to what is going on or does one shrug their shoulders and say, "Hey, it works"?
Other questions unrelated to the above: (1) How much tumor is needed to prepare the vaccine? (2) How long does it take? and (3) Should, IYHO, positive biopsies routinely be preserved and if so is that a practical thing to do? At least in my neck of the woods it is not done and that, IMHO, does not seem prudent. Thanks to anyone who may respond. Jerry
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