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Biotech / Medical : Cistron Biotechnology(CIST)$.30
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To: John Metcalf who wrote (2564)2/2/2000 10:58:00 AM
From: Walter Morton  Read Replies (1) of 2742
 
I found this on PennyPI.com:

TITLE OF INVENTION: IL-1 Muteins: Their Preparations and Method of Use to Inhibit IL-1 Activity

ENCAPSULATED IMMUNOMODULATORS USEFUL AS VACCINE ADJUVANTS
patents.ibm.com

Encapsulation of IL-1b and Vaccine Experiment:

This investigation employed four groups of female Sprague-Dawley rats. The investigation was for 58 days and the purpose was to evaluate the use of IL-1b as an adjuvant. The vaccine used for these experiments was influenza A/beijing H3N3 (Parke Davis). Each animal?s weight was recored prior to dosing on day 0, and then animals were administered 100 microliters of a sample comprising liposome encapsulated IL-1b intramuscularly. Thereafter, the animals were reweighed and their weight recorded every seven days prior to their blood being drawn for the duration of the study. On day 30, animals were administered a booster dose of the test sample. Blood was collected on days 0, 7, 14, 28, 37,and 58 for determining serum 1gG ELISA titers. Animals were observed daily for sickness or mortality. On day 58, the rats were weighed and euthanized.

Groups:

1. Influenza A/Beijing H3N3 vaccine mixed with IL-1b (no encapsulation)
2. Influenza A/Beijing H3N3 vaccine alone (no encapsulation)
3. Influenza A/Beijing H3N3 vaccine and mature IL-1b encapsulated togeter in liposomes

RESULTS: Animals receiving the liposome encapsulated IL-1b mixed with influenza A/Beijing H3N3 vaccine showed a significant increase in anti-influenza A antibody titer over those animals receiving vaccine alone or non-encapsulated vaccine/IL-1b.

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This seems to be news to me. Did you already know about this?
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