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Biotech / Medical : BIOMIRA RESEARCH (BIOM)
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To: chirodoc who wrote (47)2/3/2000 5:26:00 PM
From: chirodoc   of 72
 
Issued January 11, 2000. U.S. Patent
No. 6013779: Process for preparation of glycosides of tumor-associated carbohydrate antigens. Inventors Ting Wong and R. Rao Koganty.

I don't think I've seen a press release on this, although it may have been previously referred to as an allowed patent.

patents.ibm.com

The abstract of the patent is as follows:

Glycoconjugate antigens are prepared by preparing a hapten glycoside, especially an alpha glycoside prepared by the Fischer method, with an olefinic aglycon moiety, especially one having a non-terminal double bond, ozonolyzing the hapten glycoside with an olefinic aglycon moiety having a non-terminal double bond to form a hapten-glycoside derivative, preferably without producing Germaldehyde as a byproduct removing by-products of ozonolysis, and conjugating the hapten-glycoside derivative to a carrier.

Claim 1 is as follows:
What is claimed is:
1. A method for covalently linking a saccharide to a carrier molecule containing at least one primary amino group comprising:

reacting said saccharide in an acid medium, with an unsaturated alcohol having a non-terminal double bond;
ozonolyzing said saccharide-alcohol to form a hapten-glycoside carbonyl derivative;
reductively aminating said glycoside carbonyl compound to link said glycoside to said carrier molecule.

bc_mack
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