02/15/2000
This post is relative to NGEN
SilverD19
by: barbventuri 2/15/00 1:53 pm
Msg: 2159 of 2180
I havent't been watching the market much today. But, it looks like a broad based, market-wide rotation. Profit taking from high-flyers going into some older, safer favorites. If it keeps going down, then margin calls and fear might kick in. With small float companies, they run either way pretty quickly. With the conferences later this month, there sould be a re-focus on the DNA sector. Also, the world markets have been a little weak the last few days, and that is reflected here too.
I once had a broker explain the dynamics to me of a bull market. He said generally in a bull market, selling occurs early in the day, with buying later. In a bear market, prices tend to go up early, and sell off late. I think it's linked to what the market makers open trading at. Of course, this market is so volitile, that it can correct in hourse what would have taken months in the 1920's,
This much volume is usually a good sign for NGEN, which often makes it's biggest plays late in the day. I've got a lot of stocks that have doubled or more lately that are down today.
I imagine weaker hands are starting to wonder. Since I bought under $10, I really don't need to worry, even at $40 I'm smiling for the year. I do expect NGEN to be a major player in the new medical world and be $100 by the end of the year. A lot of folks are getting bargains today.
The day's not over yet, although it would be hard to expect an up day at this point.
Best Wishes,
Barb
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From the Yahoo AFFX board ....
NGEN(Nanogen)-better chip technology..
by: dimperial 2/11/00 4:11 am
Msg: 3143 of 3169
than Affymetrix's. Look at news on NGEN about the beta testing of their NanoChip system with UT Southwestern. "...provided 100% accuracy on all calls made in the systematic genotyping of more than 200 individuals for 12 clinically relevant Single Nucleotide Polymorphisms (SNP)" "8% of the SNP scores determined using CURRENT DNA sequencing technology WERE CORRECTED by using the NANOCHIP system" HMMM.. I wonder what the "CURRENT DNA sequencing technology" is?? Nanogen is way undervalued compared to its peers- particularly Affymetrix. As a spammer of MYGN (Myriad Genetics) since $20, I'M POUNDING THE TABLE ON NGEN WITH A $200 PRICE TARGET!! NGEN very cheap here at $58- get in while you can because this stock is taking off. Good luck fellow genomics investors!!!!
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Affx & Ngen
by: pbuchta (47/M/Staten Island, NY) 1/25/00 9:23 am
Msg: 1357 of 2182
Thanks to all the folks who helped me with this comparative analysis.
Affx & Ngen
Affymetrics can make huge arrays of segments of DNA.
Affymetrics uses this technology to create chips of huge arrays in support of genomics research,
To acquire Affymetrix chips, there is a LARGE up-front charge (~$250K). Then each chip costs around $250 each. The processing of the data from one of their chips takes 24 hours. (It used to take a week!)
Affymetrics chips of that size will never be used in diagnostics. Each of the thousands of sites on the chip is a separate test. Qualifying the manufacturing process to the satisfaction of the FDA would be an astronomical effort.
Affymetrics passive hybridization processes is difficult to control and will require more replicants of every possible base pair match so that correct matches can be positively identified.
Nanogen's technology is one that enhances the biochemical reaction between segments of DNA called hybridization.
Nanogen has initially focused on DNA-based sample analysis.
Nanogen's technology effectively increases the rate of hybridization and the specificity (the "accuracy").
Nanogen's technology can enable a customer to make it's own chips for research. (No other company can provide this ability.)
The NGEN chips are also not limited to detection of DNA hybridization. They can also be used to detect protein-protein, enzyme-substrate, and antibody-antigen interactions.
NGEN has mentioned drug-screening applications.
Nanogen?s use of electronically mediated active hybridization to move and concentrate target DNA molecules accelerates hybridization so that hybridization may occur in minutes rather than the hours required for passive hybridization techniques. (Affx's 24 hours!)
In contrast to passive arrays, Nanogen's technology can accommodate both short and long single-stranded fragments of DNA. The use of longer probes increases the certainty that the DNA, which hybridizes with the capture probe, is the correct target.
Nanogen's electronic multiplexing feature allows the simultaneous analysis of multiple tests from a single sample. Sites on a conventional DNA array cannot be individually controlled, and therefore the same process steps must be performed on the entire array. ($$$$ using Affy?s array.)
Nanogen seeks to become the industry standard for targeted genetic analysis. (Criminal forensics. I bet the FBI will have more than a few of these units.) (Headed for FDA standards approval? We?ll see. More on this later in the game.)
Finally, concerning assay amplification. Strand Displacement Amplification ("SDA") is a proprietary target amplification process developed by Becton Dickinson whereby very low numbers of diagnostic targets in a test sample are enzymatically amplified to much higher levels, greatly simplifying accurate detection of these targets with the Nanogen system.
Affx may be first in production, but you know the old saying. Haste makes waste.
Questions? Comments?
Take it away Nanogen?
Peter
pbuchta@mail.med.cornell.edu
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