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Strategies & Market Trends : Options
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To: Jill who wrote (4381)3/8/2000 11:27:00 PM
From: steve mamus  Read Replies (2) of 8096
 
Jill,

Read the thread, here are my comments.

#1) Tumor necrosis therapy - can't evaluate, information
provided not sufficient to render an opinion, I am
however skeptical of this approach. Info is written
by an amateur.

#2) Vascular targeting agents - interesting but may be clincally irrelevant. It is true that under-vascularization of a tumor may confer resistance
to both chemo and RT. If this really helped I would be
surprised. May be more impt then #1

#3) VEA - yeah , yeah. Get in line. There are 200-300
candidate anti angiogenesis drugs - is this the one?
Maybe but unlikely. ENMD wannabe. If it works the holy
grail. Long shot.

#4) VTA - forget it. Been done. Doesn't work IMHO.

#5) 2c-3 could be impt. Refer to IMCLONE. Same approach. This could be big and could have clinical relevance.
Tumor targets colon ca in particular, possibly head and neck and others.

#6 The lymphoma antibodies - I like these. If really work in intermediate and high grade lymphomas could be very big. There is currently no good strategy for treatment
of recurrent hi grade large cell lymphomas. By the way Jackie O died of a high grade lymphoma.If this works would be very big. Market would expand into use to upfront RX of
all B cell lymphomas. Ref to IDEC RE: Rituxin antibody use for B cell lymphomas and Waldenstroms Macroglobulinemia (take that poet, didn't think I knew any big words huh)and Bexar coming out from Coulter. I esp would like to see more info on these.

Respectfully submitted,

DoK
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