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Biotech / Medical : GZTC

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To: scaram(o)uche who wrote (691)	3/24/2000 11:09:00 PM
From: Miljenko Zuanic	Read Replies (1) of 752

<<Tumor growth is dependent upon the balance of positive and negative regulators of angiogenesis.>> Why will cancer cells generate/produce anti-angiogenic protein? Yan postulated this (not only for Angio-1 or -2) for many angiogenic/anti-angiogenic proteins two years ago. Depend on the environment and micro-conditions (presence of other regulators, stage and progress of the tumor-vasculature, genotype, ...) each of this proteins have positive and negative angiogenic characteristic. My best bets is that certain angio-proteins will have limited utility in cancer therapy, if at all. Certain downstream intracellular targets with well define biology and specificity for cancer cells growth are for now what may work for cancer, imo. At this point we do have some good results for membrane receptors as target, but hetero- and/or multiple-dimerization (where antibody miss their activity and specificity) and alternative activation and/or signaling may induce resistance and therapy failure.

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