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Biotech / Medical : CYTO
CYTO 0.3000.0%Dec 19 3:59 PM EST
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To: Jim Oravetz who wrote (7825)3/29/2000 9:50:00 AM
From: Jim Oravetz  Read Replies (1) of 8116
 
Part2:
The most widely used method for studying protein interactions is the yeast two-hybrid system. We believe that this method has numerous limitations. We have developed a different, and proprietary approach to the study of functional proteomics.

The two-hybrid system Our system
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The rate of the throughput of We will be measuring 200,000 interactions
the yeast two-hybrid systems has per month and anticipate charting signaling
been improved; however, the pathways in the human proteome in 2 to 4
methodology does not reach the years.
throughput of our technology.
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The results of the yeast two- Results are passed through a series of
hybrid method may be misleading, bioinformatic filters, such as affinity and
because the interactions issue expression, to better determine
determined using this method are biologically significant interactions.
not always present in human
cells.
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Researchers must possess Knowledge of a protein's role in a knowledge about a protein's role signaling pathway is determined through the in a signaling pathway prior to application of our system. using this system.
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