(COMTEX)     B: Simulations Plus Expands Discovery Market with the Licens       B: Simulations Plus Expands Discovery Market with the Licensing of its            Predictive Software to Scriptgen Pharmaceuticals Inc.                                                                                                               LANCASTER, Calif., Mar 29, 2000 (BUSINESS WIRE) --  Simulations Plus Inc.         (OTCBB:SIMU)(www.simulations-plus.com), a premier developer of drug discovery     and development simulation software for the pharmaceutical and biotechnology      industries, today announced that it has expanded into the anti-infective market   with the licensing of both its GastroPlus(TM) and QMPRPlus(TM) software programs  to Scriptgen Pharmaceuticals Inc. Scriptgen Pharmaceuticals is a leader in the    discovery of drugs to control the expression of genes. While the user market for  Simulations Plus' novel absorption simulation has grown to seventeen of the       world's leading pharmaceutical corporations, Scriptgen is the first licensee      that is dedicated to the control of gene expression. Simulations Plus is the      leading provider of absorption simulation software and related consulting         services in the world.                                                                                                                                              Scriptgen Pharmaceuticals Inc. is a leader in the discovery of drugs to control   the expression of genes. Its current programs in the anti-infectives area are     targeted to identify multiple new drug targets and lead compounds effective       against drug-resistant bacterial, fungal, and viral pathogens. Scriptgen's        products include GATE, a family of high-throughput target identification and      validation technologies, and ATLAS and SCAN, high-throughput screening            technologies for proteins and RNA targets, respectively.                                                                                                            Simulations Plus launched GastroPlus(TM) in September 1998, as the first          commercial product in its expanding suite of ADME (absorption, dissolution,       metabolism and excretion) predictive software. The four ADME characteristics      must be determined for all potential new oral drug compounds, beginning in drug   discovery. Simulations Plus software allows the pharmaceutical scientist to       assess these characteristics through computer software rather than through        traditional lab experiments. With an estimated 80 percent of all drugs on the     market being administered orally, these studies must be performed on the          majority of new compounds. The value of Simulations Plus' groundbreaking          software is that it can reduce the need for traditional time-consuming and        expensive laboratory studies, thereby accelerating drug discovery and             development.                                                                                                                                                        "We are very excited about adding Scriptgen Pharmaceuticals to our prestigious    list of GastroPlus and QMPRPlus users worldwide," said Walt Woltosz, chairman     and chief executive officer of Simulations Plus Inc. "With a strong and growing   following among the pharmaceutical giants, we are pleased to be expanding into    one of the most vibrant segments of biotechnology today -- modulation of gene     expression. Our technologies are applicable to the discovery and development of   all oral drugs, allowing for great opportunity as the science of drug discovery   expands."                                                                                                                                                           Simulations Plus Inc. is a premier developer of groundbreaking drug discovery     and development simulation software, which is licensed to and used in the         conduct of drug research by biotechnology and pharmaceutical companies            worldwide. The Company has two other businesses, Words+ Inc. and FutureLab(TM),   which are based on its proprietary software technologies and which provide        support for the emerging pharmaceutical enterprise. Simulations Plus Inc. is      headquartered in Southern California and trades on the OTCBB under the symbol     "SIMU."                                                                                                                                                             Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995  -- With the exception of historical information, the matters discussed in this    news release are forward-looking statements that involve a number of risks and    uncertainties. The actual future results of the Company could differ              significantly from those statements. Factors that could cause or contribute to    such differences include, but are not limited to: continuing demand for the       Company's products; competition; continuing customer acceptance of the Company's  products and acceptance of the Company's new products. Further information on     the Company's risk factors is contained in the Company's quarterly and annual     reports as filed with the Securities and Exchange Commission.                                                                                                                                                                                          Distributed via COMTEX.                                                                                                                                             Copyright (C) 2000 Business Wire.  All rights reserved.                                                                                                            -0-                                                                                                                                                                  CONTACT:          Simulations Plus Inc.                                                             Ron Creeley, 661/723-7723                                                         or                                                                                Banchik & Associates                                                              Doris Banchik, 805/688-2340                                                                                                                                                                                                         KEYWORD:          CALIFORNIA                                                      INDUSTRY KEYWORD: BIOTECHNOLOGY                                                                     SOFTWARE                                                                          PHARMACEUTICAL                                                  Today's News On The Net - Business Wire's full file on the Internet               with Hyperlinks to your home page.                                                                                                                                  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