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Biotech / Medical : Cell Genesys (CEGE)
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To: david james who wrote (853)4/4/2000 10:24:00 AM
From: Cheryl Galt   of 1298
 
Here's some Abgenix news, since ABGX has no active thread.
biz.yahoo.com

Paraphrased excerpts:

Apr 3 Abgenix announced it initiated its first Ph 2 multi-center, placebo controlled trial of its proprietary drug ABX-IL8, for moderate to severe psoriasis.
- anticipated enrollment - 90 pts
- interim review possible by year-end 2000.

Dec 1999 Abgenix reported results of a multi-center, placebo controlled Phase I/II
- 45 patients with moderate to severe psoriasis.
- ABX-IL8 was safe and well tolerated at all dose levels tested
- a dose-dependent improvement was seen in multiple measures of disease.

Future additional Phase II trials for ABX-IL8 are being evaluated in psoriasis and other indications including rheumatoid arthritis and cancer.
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ABX-IL8 is being studied initially in psoriasis because of its potential to intervene at multiple steps in the disease pathology by blocking IL-8.

Studies ==>
o IL-8 levels can be elevated 150-fold in psoriatic tissue vs normal tissue.
o IL-8 is also a growth factor for skin cells that are proliferating in psoriatic tissue.
o IL-8 is a potent angiogenesis factor, so it may be contributing to the ingrowth of blood vessels that nourish psoriatic tissue.
---------------

ABX-IL8 was developed using their XenoMouse technology.
It targets Interleukin-8, a cytokine that can cause unwanted inflammation by first enabling immune cells, including neutrophils, to migrate to inflammatory sites and subsequently activating them. There is substantial evidence that IL-8 contributes to a number of inflammatory diseases, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease.
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