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Biotech / Medical : Sangamo Therapeutics, Inc. SGMO
SGMO 0.500-5.6%1:30 PM EST

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To: Mike McFarland who wrote ()4/6/2000 1:31:00 PM
From: Mike McFarland  Read Replies (1) of 368
 
TWST: Give us a brief overview of Sangamo BioSciences
archive.twst.com
(snip)
The approach that we have taken is to utilize a specific class of transcription factors known as zinc finger DNA binding proteins, or "ZFPs", which are, based upon the way they recognize DNA, amenable to rational design or genetic engineering. By engineering individual zinc fingers we can cause them to recognize new sequences of DNA in a highly specific manner. We then link these engineered zinc finger protein domains with functional domains that permit us to either activate or repress a target gene. We can fundamentally control the expression of genes in any host system, including human, plant, or microbes with this technology. The company was founded in 1995 with intellectual property from four academic institutions, Johns Hopkins University, Massachusetts Institute of Technology, The Scripps Research Institute, and the Medical Research Council.
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