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Biotech / Medical : Celera Genomics (CRA)

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To: allen menglin chen who wrote (309)5/8/2000 8:54:00 PM
From: gao seng  Read Replies (1) of 746
 
nature.com today publishes the DNA sequence of human chromosome 21 as a special and freely available web pre-publication. The article will appear in print in the May 18 issue of Nature and this print version should be referred to in citations.

The Chromosome 21 Mapping and Sequencing Consortium - a panel of 62 scientists in Japan, Germany, France, Switzerland, the USA and Britain - show that chromosome 21 encompasses more than 33 million base pairs of DNA, and its publication therefore marks a major scientific milestone. The chromosome sequence reveals the organization of a number of genes linked to specific human disorders and will speed the search for several more genes linked to diseases such as Alzheimer?s and certain forms of cancer. The availability of this sequence will also provide valuable tools for investigating the basis of Down syndrome, which is caused by the inheritance of three (rather than the normal two) copies of chromosome 21.

A striking feature of the chromosome is that it contains less than 300 discernible genes, each likely to encode a protein with a specific role in our biochemical production line. Extrapolation of this observation implies that the whole human genome may contain no more than 40,000 genes, many fewer than previously thought.

nature.com
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