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Biotech / Medical : Elan Corporation, plc (ELN)
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To: Ilaine who wrote (990)6/6/2000 1:58:00 PM
From: Pseudo Biologist  Read Replies (1) of 10345
 
This report is a little weird, because TNF-alpha is a cytokine, not a gene.

Not really that weird, a cytokine is, of course, a protein and proteins are coded by genes. So we have gene (DNA) => mRNA => protein. If you block the gene or the mRNA, say with antisense, then you prevent the protein from ever being produced. Remicade and Enbrel work at the protein level interacting with, and neutralizing, the TNF-alpha cytokine. Blocking the specific gene itself should, in theory, achieve the same purpose.

PB
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