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Biotech / Medical : Neurocrine Biosciences (NBIX)

NBIX 139.38

-1.7%

12:53 PM EST

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To: scaram(o)uche who wrote (588)	6/6/2000 10:45:00 PM
From: Miljenko Zuanic	Read Replies (1) of 1834

<<Neurocrine holds patent positions on MCRs 1-5 through exclusive and non-exclusive patent licenses >> For first time they directly mentioned all 5 receptors. More confident in patents portfolio? What about PCOP-Roche? Anyway, insomnia continue to be hot area in pharmaceutical fields: biz.yahoo.com <<Physicians regard the newer, nonbenzodiazepine hypnotics, including zolpidem (Searle's Ambien; Sanofi-Synthelabo's Stilnox), zopiclone (Aventis's Imovane; Chugai's Amban), and zaleplon (Wyeth-Ayerst's Sonata) as offering benefits over benzodiazepines in terms of reduced abuse potential, rebound insomnia, and hangover effect. Physicians believe that zaleplon's ultra-short duration of action confers an advantage over other available hypnotics in that it can be administered in a more flexible manner; however, in some patients zaleplon's mechanism of action is too short to sustain sleep throughout the night. Perhaps the most promising agents in development for insomnia are melatonin receptor agonists (such as Servier's agomelatine [S20098]), which physicians anticipate will enable effective pharmacological treatment of circadian rhythm disorders.>> Miljenko PS: BTW, I am sure that if MYGN tomorrow report discovery of the new MCR-6 gene, they will jump another +20 points. <g>

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