Sumitomo interest?
United States Patent 6,077,829
Tanaka , et al. June 20, 2000
--------------------------------------------------------------------------------
Stable pharmaceutical composition of BDNF
Abstract
A stable pharmaceutical composition of brain derived neurotrophic factor (BDNF) in the form of an aqueous solution or lyophilized one being suitable for a long-term storage, which contains a surfactant, especially nonionic surfactant (e.g., Tween 80) of 0.001 to 10%, whereby the polymerization and the denaturation of BDNF are inhibited, and the biological activities of BDNF are maintained for a long time. The lyophilized composition can be made more stable by addition of a sugar alcohol (e.g., mannitol) and/or an amino acid (e.g., glycine).
--------------------------------------------------------------------------------
Inventors: Tanaka; Katsumi (Takatsuki, JP); Kumano; Masashi (Mino, JP)
Assignee: Regeneron Pharmaceuticals, Inc. (Tarrytown, NY); Sumitomo Pharmaceuticals Company, Limited (Osaka-fu, JP)
Appl. No.: 180884
Filed: November 16, 1998
U.S. Class: 514/21; 514/12
Intern'l Class: A61K 038/22
Field of Search: |
