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Biotech / Medical : Biotech News
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To: Jim Oravetz who wrote (149)7/12/2000 1:05:05 PM
From: Jim Oravetz  Read Replies (1) of 7143
 
Modified HIV may be effective for delivering and regulating gene therapy

By LESLIE H. LANG
UNC-CH School of Medicine

CHAPEL HILL -- HIV, the virus that causes AIDS, may be adapted for use in gene therapy to treat genetic diseases and immune system disorders including AIDS itself, according to a University of North Carolina at Chapel Hill scientist.

New findings released June 24 in the journal Molecular Therapy provide the first evidence that a genetically stripped-down amalgam of HIV components not only can safely deliver genes to target cells in the body, but can be fashioned with a molecular switch system that turns these genes off in response to a common antibiotic.

This accomplishment was achieved without toxic affects in laboratory rats. It suggests that doctors may someday be able to control gene expression in people who are treated with gene therapy vectors based on HIV.

unc.edu

Jim
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