Robert, if you found it 4 months ago, you click a lot faster than I do. It was issued 30 May.
United States Patent
6,069,126
Abruzzo , et al.
May 30, 2000
Antifungal combination therapy
Abstract
There is described antifungal combination therapy comprising the use of known antifungal agents such as the azoles or
polyenes in combination with a pneumocandin derivative antifungal agent. More particularly, the invention relates to
antifungal combination therapy comprising the use of azoles such as fluconazole, voriconazole, itraconazole, ketoconazole,
miconazole, ER 30346, SCH 56592; polyenes such as amphotericin B, nystatin or liposomal and lipid forms thereof such
as Abelcet, AmBisome and Amphocil; purine or pyrimidine nucleotide inhibitors such as flucytosine; or polyoxins such as
nikkomycins, in particular nikkomycin Z or other chitin inhibitors, elongation factor inhibitors such as sordarin and analogs
thereof, mannan inhibitors such as predamycin, bactericidal/permeability-inducing (BPI) protein products such as XMP.97
or XMP.127 or complex carbohydrate antifungal agents such as CAN-296 in combination with a pneumocandin
derivative as described herein.
Inventors:
Abruzzo; George K. (Clark, NJ); Bartizal; Kenneth F. (Somerset, NJ); Flattery; Amy M.
(Sayreville, NJ)
Assignee:
Merck & Co., Inc. (Rahway, NJ) |
