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Biotech / Medical : Biotransplant(BTRN)

BTRN 35.46

+0.1%

Dec 5 4:00 PM EST

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To: sim1 who wrote (617)	8/2/2000 6:32:44 PM
From: nigel bates	Read Replies (1) of 1475

ML Labs press release (I couldn't get it all as my browser thinks their site is screwy - or vice versa) mllabs.com (01/08/2000) Crucial discovery resulting from research into rejection of transplant organs Research funded by ML Laboratories PLC published today in the scientific journal Nature Immunology has demonstrated for the first time that an immune response in a host responsible for rejecting foreign cells can be blocked. The research, undertaken by Professor Robert Lechler and the immunology team at the Hammersmith Hospital in London has succeeded in preventing the immune system of a host from identifying transplanted cells as foreign. The studies carried out in mice transplanted with porcine pancreatic xenografts demonstrated significantly prolonged survival following immunisation to induce an antibody blocking response. This approach known as donor-specific co-stimulatory blockade, offers the potential major benefit of removing the need for long term immunosuppression following transplantation. Professor Robert Lechler, Head of the Immunology team at the Hammersmith commented: "Our findings offer a novel solution in the battle to get foreign organs accepted by human bodies." "Our first models using cells from the pancreas have been successful and we are now taking these findings on to further, more complex models. Eventually, we hope that using foreign organs in humans may start to solve the huge shortage of organ donors across the world." Lord Winston, director of Research and Development at Hammersmith Hospital, praised Professor Lechler’s work: "Several thousand people a year die awaiting organ transplants in this country and there are probably more patients, who because of the shortage of donors, never get on the waiting list." "This remarkable work is a major advance in obtaining donor organs which could save many lives every year." Stuart Sim, CEO of ML Laboratories added: "We believe the ground breaking research carried out by Professor Lechler and his team has resulted in a crucial discovery which heralds a significant advance in this exciting field and may pave the way for foreign organs to be accepted by the human body helping the thousands desperately awaiting transplants where improvements in donor organ availability are not expected to keep pace with demand." "It is our inten...."

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