Essential Therapeutics (ETRX) formerly Microcide (MCDE Message Board

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Biotech / Medical : Essential Therapeutics (ETRX) formerly Microcide (MCDE

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To: sim1 who wrote (282)	8/19/2000 1:20:49 PM
From: tuck	Read Replies (1) of 415

S. SILEN & T. ROCKRAT Silicon Investor Bile-ogical Association (SIBIA), Somewhere in Ca. The effects of chronic capillary development on forearm adenosine triphosphate (ATP) depletion and lactic acid expression in acute murine depression models. In this dose ranging study a subject experienced in murine depression (mouse clicking) was monitored while continuously cutting and pasting abstracts for two hours. We hoped to determine whether or not chronic administration of several hours per day of intermittent murine depression led to sufficient capillary enhancement of the forearm to allow the subject to withstand acute murine depression for shorter periods of time. The subject has been observed intermittently cutting and pasting for years. In this initial study, the dose was two continuous hours, as the subject stopped for breakfast. ATP and lactic acid levels were monitored every 5 minutes, and a laboratory standard MS Mouse was used for the murine depression model. After half an hour ATP depletion reached equilibrium with lactic acid expression and remained stable for the remaing 90 minutes till breakfast, with the subject continuously operating at 90% of his fastest murine depression. Our results indicate that chronic intermittent murine depression can lead to the kind of forearm capillary development that allows acute murine depression. Further study is needed to see how long this acute murine depression lasts. Stuart, are you done with breakfast yet? Back in front of your monitor, you rat! All kidding aside, many thanks for your efforts. I'm finding the directions they're taking in screening and bioarrays particularly interesting. I'm hardly omniscient in this area, but I don't know of another outfit with MCDE's focus here. Cheers, Tuck (aka RockRat)

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