Mark,
Regn did conduct study on the neuroprotective/neurogrow property for the their NGF in several indications, included Parkinson's. Reason that they selected (IMO) ALS if pure financial. Because the experience of the NGF for CNS disorder is very limited (not only for regn), they started with indication where are no therapy. This is their learning lesson #2 (CNTF is #1).
Recently regn (also ctii, gne, amgn,...) realize that combination of the two or more tropic factor will have better therapeutic effects than single one, for any CNS neurodegenerative disorder.
NGF have two property: 1) protect glials/neuron cells from further destruction and 2) regeneration of the (recent science demonstrated that this are possible) distracted CNS region.
Normally, that protection is easy than regeneration, and at progressed disease are harder to have sufficient positive therapeutic effects. There are no cure for any CNS disorder, only slowing the disease progression.
Regeneration of the effected area with implant cells is (IMO) for now far from any research progress. I do not know about Diacrin work, and will have to do some homework.
Hope, this can help a little.
mz |
