Anyone noticed this on one of the Humab threads? (& if you're capable of more informed comment than I am, please share...) -
Message 14403402
"...Söderlind and his colleagues have developed a technology that allows them to vary all six CDRs of an antibody simultaneously into one single antibody framework. The result is a much larger range of potential recombinations, yielding antibody libraries with high genetic diversity--and since all of them originate from the human immune system, the potential for an immune reaction is minimal...."
Reference: "Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries," E Söderlind, L Strandbert, P Jirholt, N Kobayashi, V Alexeiva, A-M Åberg, A Nilsson, B Jansson, M Ohlin, C Wingren, L Danielsson, R Carlsson & CAK Borrebaeck, Nature Biotechnology, vol. 18, no. 8, p. 852-856.
An abstract of this article can be viewed at: nature.com journal/v18/n8/abs/nbt0800_852.html |
