XOMA. Bull or Bear? Message Board

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Biotech / Medical : XOMA. Bull or Bear?

XOMA 32.31

+1.4%

Nov 26 3:59 PM EST

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To: Robert K. who wrote (14766)	9/20/2000 12:10:17 AM
From: Bluegreen	Read Replies (3) of 17367

Bob, I would of approached this as Neuprex being STRICTLY an antibiotic synergist. NOT trying to reverse a G 8 or above sepsis event. IF YOU HAVE LEARNED ANYTHING FROM THIS LATEST TRIAL LEARN THIS............USE NEUPREX AS A PREVENTION OF FULL BLOWN SEPSIS NOT REVERSAL! USE IT TO RAPIDLY AND EFFECTIVELY KILL GRAM NEG BUGS BEFORE THE LOAD OF THIER LPS BROKEN UP MEMBRANES GET SO HIGH TO TRIGGER THE CASCADE!!! Take advantage also of BPI's ability to sop up LPS EARLY AND NOT SO MUCH TO TRIGGER CD14!!!!!! Just my opinions but the ONLY real definitive study with a mammal by direct gram neg bug infusion was the Baboon study. I take great comfort in commentary and Xoma agreeing that EARLY administration is important. ONE MORE TIME.....rapid AND effective killing EARLY on of gram neg bugs is VITAL!!! DO everything you can to prevent load buildup of LPS and kick off of CD14. Only way to prevent buildup is by preventing progeny appearance. If there is too much LPS to sop up even IF you have enough BPI you still will get vicious cycle of CD14 kickoff by the load. Once again only my opinions.

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