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Biotech / Medical : Vertex Pharmaceuticals (VRTX)

VRTX 437.17

+0.6%

Nov 14 9:30 AM EST

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To: 2MAR$ who wrote (439)	10/2/2000 7:55:04 PM
From: Miljenko Zuanic	Read Replies (1) of 1169

What about caspases? biz.yahoo.com <<Proteases function by cleaving and activating proteins, and play an important role in the regulation of numerous biological processes, including viral replication and activation of the immune response. Proteases have been implicated as contributors to several diseases, including Alzheimer's disease, hypertension, cancer and viral infections. There are numerous examples of marketed drugs that achieve a therapeutic effect by inhibiting protease activity, including HIV protease inhibitors for the treatment of HIV and AIDS, and angiotensin converting enzyme (ACE) inhibitors for the treatment of hypertension. "In addition to the hepatitis C NS3-4A serine protease, this patent broadly applies to other proteases, including those which may be the subject of Vertex drug discovery efforts. As part of our chemogenomics approach to drug discovery, we are seeking to develop proprietary technologies that we can integrate into our drug discovery platform, with particular emphasis on technologies that enhance our ability to pursue drug design across families of related protein targets," said Sato.>>

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