Dear Myron
it gets very difficult to explain human pharmacology to a lay person ; I don't intend
to sound condescending but that is the problem . I don't want to bore
with the details so I 'll keep it simple:
The best and quickest way for you to learn the truth about phentolamine is to ask your
pharmacist or a cardiologist if you have or know of one.
Here is what I know ( off the top of my head because I heven't used
phentolamine and I leave all my books in the office.
Phentolamine /Regitine has been around for years ,~ >30. Doctors
are inquisitive folks by nature and as soon as they find that a drug
works for a disease by one route, IV for example, them around the
world start tinkering with it by intra muscular , oral, as an enemma,
put it on your skin, on your hair etc etc for any number of diseases,
first in animals and then in humans . It is called experimentation.
( I hope I haven't lost anybody so far ,ESPECIaLLY EDDERD because I know
how he feels about pharmacology!!!!( just kidding Eddie ).
Alright we now have had Regitne in use for 30 years by IV and IM ( as
well recently through relatively unapproved 'gray aerea' of penile
injections> However Doctors being very knowlegable folks are allowed
to use approved drugs for yet tobe approved uses ( penile inj. ) as
long as they are willing to suffer the legal consequences. Generally
speaking when most of them suceed in such an unofficial drug delivery
nobody complains and the FDA closes one eye. Not infrequently after
years of successful unoffical use of a drug somebody finally runs " an
official study " and the FDA finally gives the official OK . I think this
is how it goes . Am i correct Eddie?
So if Regitine has been around for yers and given in the large doses
IV and IM don't you think some patient would have complained of getting
erections and the Doc noticed it and written up about it : hey, we got an
impotence cure!! Yet not a whisper in thirty years.
Further more whereas most drugs come in 3 forms IV , IM , and orally
( sometimes 5' enamas and skin lotions or eye ointm etc that darn
Regitine IS NOT MADE FOR oral use . Nobody here wonder why ?
Well because there is a good reason(s): it either doesn't work and/or is
unsafe or both. To be honest with yoy I DON't KNOW why Regitine hasn't
been made in oral form all these years. My guess from what I read
is that it is rapidly metabolized , within minutes after infusion. this
is why it has to be given by continuous IV drip. Also because it
is a POWERFUL VASODILATOR that produces severe Hypotension; so that it
is currently approved officially only for 1) therapy of severe Hypetensive
emergencies in particular those caused by the tumor Pheochromocytoma
2) to prevent skin necrosis from Dopamine infiltration ( don't have time
to explain that3 after load reduction therapy for sever cogastive heart
failure in the INT care unit. Tis the 2nd and last time I am ging over
Regitine.Ask your Doc and Pharm. D for morer deteils. Oral regitine for
impotenc? The studies you quote I haven't read but I am fairly
confident they are a fraud like Bre-X mines.
I don,t know what happened at the stockholder's meeting. My guess from
what I know is that the company is very comfortable with the sales
and outlook of their product/and manufacturing enterprise and don't
really care too much about Stock market gyrations. Time will tell
So long guys > Gone fishing for Memorial day! See ya Tuesday. ( I warn
you though no more free educetional info on Pharmacology. As of Tuesday
there will be a small charge ). |
