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Biotech / Medical : Neuroscience
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To: Marty who wrote (128)11/2/2000 6:43:55 PM
From: Nikole Wollerstein  Read Replies (1) of 278
 
Thanks for the reference
I noticed strange discrepancies:
This is from paper: "A possible explanation for the 38 kDa protein isolated by PABA may be the enzyme heme oxygenase 2. As mentioned before, AIT-082 shows the
ability to induce production of neurotrophic factors by modulating carbon monoxide-dependant guanylyl cyclase(cGMP) ( AIT-082ís induction of cyclic guanylyl cyclase was linked to carbon monoxide when researchers found that AIT-082 administration with
zinc protoporphyrin (ZnPP) resulted in an absence of effect. ZnPP is a carbon monoxide scavenger and its inhibitory effect suggests the cooperation of
carbon monoxide, a known neurotransmitter, in AIT-082ís molecular mechanism. "

This is from the 1998 Abstract:
"The effects of AIT-082, a unique purine derivative under development for Alzheimer's disease, on
intracellular conc. of cAMP, cGMP and Ca2+ were studied in cultured neurons and astrocytes by AIT-082 (100 µM) induced an increase in the
intracellular conc. of cAMP and this stimulation was additive with the beta-adrenergic agonist,
isoproterenol-induced increase in cAMP in astrocytes. AIT-082 has no significant effect on Ca2+ influx
and is not involved in the cGMP system in both cerebellar granule cells and astrocytes.
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